Monitor Closely (2)pentobarbital will lessen the level or impact of suvorexant by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Check. Solid CYP3A4 inducers could lower suvorexant efficacy; if amplified suvorexant dose necessary, will not exceed twenty mg/working daypentobarbital will reduce the extent or outcome of lonafarnib